Biopsy Examination Validity Based on Narrow Band Imaging Guidance of Nasopharyngeal Carcinoma Suspected Patients

AbstractThe diagnosis of nasopharyngeal carcinoma (NPC) is established based on histopathological examination results of tumor tissue in nasopharynx and narrow band imaging (NBI) which is an imaging technique that utilizes specific displacement and light absorption characteristics of a specific wavelength. It has not known yet the validity of nasopharyngeal biopsy examination results based on NBI guidance and blind biopsy as a golden standard in establishing nasopharyngeal carcinoma diagnosis. Analyzing the validity of the nasopharyngeal biopsy examination results through NBI guidance and blind biopsy as a golden standard in nasopharyngeal carcinoma diagnosis. NPC patients performed biopsy using NBI then performed blind biopsy and the results of both examinations were analyzed. Histopathologic examination results of blind biopsy were 23 samples with NPC positive (52.3%) and 21 samples with NPC negative (47.7%). On histopathology examination using NBI guidance 34 samples (77.3%) were positive malignant cells and 10 samples (22.7%) were negative malignant cells. It was calculated and obtained the following results; sensitivity  = 95.7%, specificity = 42.9%, positive predictive value = 64.7%, negative predictive value = 90.0%, and accuracy = 70%. Furthermore, statistical analysis using McNemar comparative test and Kappa association test were performed. In McNemar comparative test obtainedp value  =&thin...
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - Category: ENT & OMF Source Type: research

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In conclusion, it was proposed that CDK1, SMC4, KNTC1, KIF23, AURKA and ATAD2 may be involved in the tumorigenesis of NPC. Furthermore, they may be utilized as molecular biomarkers in early diagnosis of NPC. PMID: 31516577 [PubMed]
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Authors: Zhang X, Ye Y, Fu M, Zheng B, Qiu Q, Huang Z Abstract The Epstein-Barr virus (EBV) is tightly associated with a variety of human tumors, including Burkitt lymphoma and acquired immune deficiency syndrome-related lymphoma of B-cell origin, as well as nasopharyngeal carcinoma and gastric cancer of epithelial origin. The virus latently infects the host cells and expresses proteins and non-coding RNAs to achieve malignancy. MicroRNAs (miRNAs or miRs) are small RNAs consisting of 19-25 nucleotides, which directly bind to the 3'-untranslated region of mRNAs to promote degradation and inhibit translation of mRNAs...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Publication date: Available online 12 September 2019Source: Seminars in Cancer BiologyAuthor(s): Chi Man Tsang, Vivian Wai Yan Lui, Jeffrey P. Bruce, Trevor J. Pugh, Kwok Wai LoAbstractNasopharyngeal carcinoma (NPC), also named the Cantonese cancer, is a unique cancer with strong etiological association with infection of the Epstein-Barr virus (EBV). With particularly high prevalence in Southeast Asia, the involvement of EBV and genetic aberrations contributive to NPC tumorigenesis have remained unclear for decades. Recently, genomic analysis of NPC has defined it as a genetically homogeneous cancer, driven largely by NF-&...
Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research
In this study, we overexpressed LMP1 in two NPC cell lines and found elevated level of cytokeratin 19 (CK19) expression. CK19 is an undifferentiated keratin and a stem cell marker. We also have found an increased number of ALDH positive cells along with LMP1 overexpression in both cell lines. Our data demonstrate that LMP1 regulates the maintenance of ALDH-1 positive NPC cancer stem cells, thus shedding light on target therapy of NPC in clinical application. Keywords: nasopharyngeal carcinoma; latent membrane protein 1; aldehyde dehydrogenase; cancer stem cells. PMID: 31507199 [PubMed - in process]
Source: Acta Virologica - Category: Infectious Diseases Authors: Tags: Acta Virol Source Type: research
This study explored to investigate whether skeletal muscle loss after chemoradiotherapy (CRT) in nasopharyngeal carcinoma (NPC) patients can predict survival.MethodsA total of 394 non ‐metastatic NPC patients were enrolled. The cross‐sectional area of the third lumbar skeletal muscle based on computed tomography (CT) scan was measured and the skeletal muscle index (SMI) was calculated. A cut‐off value suitable for the Chinese population was used to define sarcopenia, and re lative changes in skeletal muscle after treatment were analyzed for the confirmation of skeletal muscle tissue loss during treatment and its impa...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
Conclusions: Higher serum cotinine level is associated with higher seropositivity for EBV serological markers in healthy men in southern China. Such positive association was also observed in women but became non-significant. If confirmed to be causal, this finding has important implications for tobacco control and prevention of EBV-related disease, particularly for NPC.
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
CONCLUSION: There is no evidence of benefit from the addition of cetuximab to standard management protocols, and there is some evidence of increased toxicity. There is more promise for its use in metastatic or locally recurrent settings. This review draws together the existing evidence and could provide a focus for future studies. PMID: 31506113 [PubMed - as supplied by publisher]
Source: Journal of Laryngology and Otology - Category: ENT & OMF Tags: J Laryngol Otol Source Type: research
Pulmonary lymphoepithelioma-like carcinoma (LELC) is a rare and unique subtype of primary non-small cell lung cancer (NSCLC) that histologically resembles undifferentiated nasopharyngeal carcinoma (NPC) [1]. It is recognized to be etiologically associated with Epstein-Barr virus (EBV) infection in endemic area [2]. Currently, pulmonary LELC is classified as “other and unclassified carcinomas” according to the 2015 World Health Organization Classification Lung Tumors [3]. Over the past decades, less than 600 cases have been reported in the literature.
Source: Lung Cancer - Category: Cancer & Oncology Authors: Source Type: research
This study aimed to evaluate the prognostic value of combining pretreatment Epstein ‐Barr virus (EBV) DNA level and cervical node necrosis (CNN) for patients with nasopharyngeal carcinoma (NPC) receiving intensity‐modulated radiotherapy (IMRT). A total of 607 incident nonmetastatic NPC patients treated with IMRT ± chemotherapy were reviewed. Patients were divided into four g roups based on EBV DNA level and CNN status. The primary endpoint was progression‐free survival (PFS). Kaplan‐Meier curves with log‐rank test were applied to compare survival outcomes and the Cox proportional model was used t...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
Condition:   Nasopharyngeal Carcinoma Intervention:   Sponsor:   Zhongshan People's Hospital, Guangdong, China Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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