Evidence-based use of acetaminophen for hemodynamically significant ductus arteriosus in preterm infants

While cyclooxygenase inhibitors have been the most common medications used to facilitate earlier closure of patent ductus arteriosus in preterm infants, adverse effects and variable efficacy have highlighted a need for alternative options. Acetaminophen facilitates ductal closure via an alternate pathway of prostaglandin inhibition. Despite treatment with high doses, toxicity is uncommon in preterm infants, possibly due to immature hepatic metabolism. Pooled data from randomized clinical trials of early treatment demonstrate that acetaminophen has similar efficacy as cyclooxygenase inhibitors for PDA closure with a favourable side effect profile and without any apparent increase in adverse neonatal outcomes.
Source: Seminars in Perinatology - Category: Perinatology & Neonatology Authors: Tags: 42/4 Source Type: research