Severe combined immunodeficiency in Sting V154M/WT mice

Sting V154M/WT mice develop an IFN-independent severe combined immunodeficiency with hypogammaglobulinemia, a partially IFN-dependent T cell proliferation defect, and variable lung and kidney inflammation, providing new clues in the understanding of STING gain-of-function pathophysiology.

Source: Journal of Allergy and Clinical Immunology - May 23, 2018 Category: Allergy & Immunology Authors: Delphine Bouis, Peggy Kirstetter, Florent Arbogast, Delphine Lamon, Virginia Delgado, Sophie Jung, Claudine Ebel, Hugues Jacobs, Anne-Marie Knapp, Nadia Jeremiah, Alexandre Belot, Thierry Martin, Yanick J. Crow, Isabelle Andr é-Schmutz, Anne-Sophie Korga Source Type: research