Time-varying coefficient of determination to quantify the explanatory power of biomarkers on longitudinal GFR among children with chronic kidney disease

Coefficients of determination (R2) for continuous longitudinal data are typically reported as time-constant, if they are reported at all. The widely used mixed model with random intercepts and slopes yields the total outcome variance as a time-varying function. We propose a generalized and intuitive approach based on this variance function to estimate the time-varying predictive power (R2) of a variable on outcome levels and changes.
Source: Annals of Epidemiology - Category: Epidemiology Authors: Tags: Original article Source Type: research