5. Modeling Synovial Sarcoma from initiation through metastasis

Synovial Sarcoma is the most common soft tissue sarcoma in adolescents and young adults. The prognosis for patients that have acquired metastatic synovial sarcoma is poor. We have been able to model this neoplastic in mice and the disease mirrors human sarcoma, histologically and molecularly. PTEN appears to be a major driver to metastasis.
Source: Cancer Genetics and Cytogenetics - Category: Genetics & Stem Cells Authors: Source Type: research