7. Clinical implications of cytogenetic heterogeneities in BCR-ABL1 fusion positive adult B cell acute lymphoblastic leukemia

Cytogenetic heterogeneities including additional chromosomal abnormalities (ACAs) are frequently observed in adults with t(9;22)(q34.1;q11.2)/BCR-ABL1 positive B cell acute lymphoblastic leukemia (Ph+B-ALL). We retrospectively investigated such heterogeneities/ACAs in 144 adults with Ph+B-ALL to assess their clinical implications. There were 85 (59.1%) men and 59 (40.9%) women with a median age of 54-years. Patients were sorted into 6 subgroups based on the karyotypic findings in stemline including: 32 (22.2%) with t(9;22) as the sole aberration, 23 (15.9%) with t(9;22) plus one ACA, 26 (18.1%) with t(9;22) as part of a complex karyotype, 18 (12.5%) showed a variant/complex t(9;22), 30 (20.8%) showed t(9;22) as the stemline with ACAs in the sideline(s), and 15 (10.4%) had the t(9;22) and hyperdiploidy.
Source: Cancer Genetics and Cytogenetics - Category: Genetics & Stem Cells Authors: Source Type: research