SBRT for pancreatic cancer: In regard of Bohoudi et al.
SBRT for pancreatic cancer: In regard of Bohoudi et al. Radiother Oncol. 2018 May 11;: Authors: Bohoudi O, Bruynzeel AM, Senan S, Cuijpers JP, Slotman BJ, Lagerwaard FJ, Palacios MA PMID: 29759683 [PubMed - as supplied by publisher]
ConclusionsThe relevance of SPARC expression in pancreato-biliary carcinomas though may still be important for therapeutic decision making, it is not responsible for peritumoral stromal desmoplasia in these tumors and it does not have any significant prognostic implication.
Conditions: Pancreatic Cancer; Metastatic Pancreatic Cancer Intervention: Drug: nab paclitaxel plus gemcitabine Sponsors: Asan Medical Center; Bundang CHA Hospital; Ulsan University Hospital Recruiting
ConclusionsModeling choices can have a substantial impact on VOI. Therefore, it is important for groups working to incorporate VOI into research prioritization to adhere to best practices, be clear in their reporting and justification for modeling choices, and to work closely with the relevant decision makers, with particular attention to modeling choices.
British Journal of Cancer, Published online: 21 October 2019; doi:10.1038/s41416-019-0604-5YY1 targets tubulin polymerisation-promoting protein to inhibit migration, invasion and angiogenesis in pancreatic cancer via p38/MAPK and PI3K/AKT pathways
ConclusionsFor accurate staging, at least 12 LNs should be retrieved. The three ‐tier N staging system is valid for clinical practice and has a more accurate prognostic predictability than the two‐tier system.
Nature Reviews Gastroenterology &Hepatology, Published online: 21 October 2019; doi:10.1038/s41575-019-0231-xFungi promote pancreatic cancer
Contributors : Y Li ; F Huang ; S ZhangSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensGlucose metabolism makes contributions to the development of pancreatic ductal adenocarcinoma (PDAC). Meanwhile, circular RNAs, a subset of noncoding RNAs, plays an important role in glucose metabolism and cancer progression. Analysis of low-glucose-treated and normal-glucose-treated MIA PaCa-2 cells from 6 samples (3 samples each group) was conducted. Results indicate insight into molecular signature of the pathogenesis of PDAC in abberant glucose metabolism.
Journal of Natural ProductsDOI: 10.1021/acs.jnatprod.9b00755
Publication date: Available online 18 October 2019Source: Advances in Biological RegulationAuthor(s): Shaw M. Akula, Saverio Candido, Stephen L. Abrams, Linda S. Steelman, Kvin Lertpiriyapong, Lucio Cocco, Giulia Ramazzotti, Stefano Ratti, Matilde Y. Follo, Alberto M. Martelli, Ramiro M. Murata, Pedro L. Rosalen, Bruno Bueno-Silva, Severino Matias de Alencar, Marco Falasca, Giuseppe Montalto, Melchiorre Cervello, Monica Notarbartolo, Agnieszka Gizak, Dariusz RakusAbstractImproving the effects of chemotherapy and reducing the side effects are important goals in cancer research. Various approaches have been examined to enhan...
Conclusions: PDO with neoprene-based glue is a safe technique that equalizes early outcome of selected patients at high risk of POPF to those at low risk undergoing PJA. Neoprene-based PDO, however, triples the risk of diabetes at 1 and 3 years.