Hepcidin and Anemia in Surgical Critical Care: A Prospective Cohort Study*

Objective:
Because anemia of inflammation is common in ICU patients and hepcidin is the key regulator of iron homeostasis, we examined time-dependent changes in hepcidin, erythropoietin, iron, and inflammatory markers in surgical ICU patients with anemia.
Design:
Prospective single-center clinical noninterventional study.
Setting:
Surgical ICUs; U.S. university hospital.
Patients:
One hundred surgical adult ICU patients.
Measurements and Main Results:
Time-dependent changes in serum hepcidin, hematologic, and erythropoietic studies were performed on ICU admission and at serial time-points through day 28, and correlated with hematologic and iron parameters and inflammatory response. Median serum hepcidin levels were significantly increased at ICU admission and decreased over time (144–36 ng/mL; p

Source: Critical Care Medicine - May 17, 2018 Category: Emergency Medicine Tags: Online Clinical Investigations Source Type: research