Randomised controlled trial tests azithromycin efficacy for asthma exacerbation

Randomised controlled trial tests azithromycin efficacy for asthma exacerbationWed, 05/16/2018 - 15:05News blog
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news

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Publication date: Available online 5 December 2018Source: Microbial PathogenesisAuthor(s): Maneesha Palipane, John D. Snyder, Kim S. LeMessurier, Anna K. Schofield, Stacie N. Woolard, Amali E. SamarasingheAbstractAsthma and influenza are leading causes of worldwide morbidity and mortality. Although these two conditions can co-exist in the same patient, the immune parameters that impact disease outcomes are not fully elucidated. The importance of macrophages to both conditions suggested a role for CD14, a co-receptor for endotoxin, as a regulatory mechanism for innate immune responses during asthma and influenza co-morbidit...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
We describe a case of fungal and bacterial infections that developed after BT. Bronchial thermoplasty (BT) is a bronchoscopic treatment for severe asthma. A 35 ‐year‐old woman with uncontrolled severe asthma despite maximal pharmacological treatment underwent BT and started coughing after the first procedure. One month later, during the second BT procedure, there were white ulcerous lesions on the right B9 bronchus. Culture of the bronchial brushing sp ecimen showedAspergillus fumigatus, for which voriconazole was started for treatment. On the third BT procedure, endobronchial mucus sampling demonstratedNocardia spp., ...
Source: Respirology Case Reports - Category: Respiratory Medicine Authors: Tags: Case Report Source Type: research
Publication date: Available online 24 November 2018Source: Respiratory Medicine Case ReportsAuthor(s): Shuko Hirota, Yoichi Kobayashi, Takashi Ishiguro, Takashi Nishida, Naho Kagiyama, Yoshihiko Shimizu, Noboru TakayanagiAbstractA 56-year-old woman was referred to our hospital for recurrent asthma of 20 years duration. She was diagnosed as having allergic bronchopulmonary aspergillosis on the basis of clinical symptoms, peripheral blood eosinophilia, elevated total serum immunoglobulin E value, positive results of specific IgE and precipitating antibodies against Aspergillus sp., central bronchiectasis, and mucoid impactio...
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
Conference abstracts
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news
Conclusions: In a population of children with SCD, allergic sensitization was associated with decreased risk of ED visits (total, for pain, and for fever). The mechanism for an association between atopy and a less severe phenotype of SCD is unclear. These findings point to potential differences in immunologic endotype/phenotype and add support to the hypothesis that lower airway disease in children with SCD has a different mechanism than typical childhood atopic asthma. Further investigation into the immunologic phenotypes and mechanisms of lower airway disease in children with SCD is warranted.1All IRR presented are per a...
Source: Blood - Category: Hematology Authors: Tags: 114. Hemoglobinopathies, Excluding Thalassemia-Clinical: Poster III Source Type: research
Conditions:   Aspergillosis;   Asthma Interventions:   Drug: PC945;   Drug: Placebo Sponsor:   Pulmocide Ltd Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conference abstracts
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news
Conference abstracts
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news
Introduction: Allergic Bronchopulmonary Aspergillosis(ABPA) most commonly presents with poorly controlled asthma &wheezing. Radiological features include central bronchiectasis &mucus impaction of airways.ABPA presenting as lobar collapse is relatively uncommon.Aim: To study clinical and radiological features of patients with ABPA(non-CF) presenting with lobar collapse.Method: A retrospective analysis of case records of patients diagnosed with ABPA from 2007-2017 at NNUH was done. Clinic letters, radiographic images and laboratory test records were reviewed.Results: A total of 10 patients were identified(n=111,9%)....
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Clinical Problems Source Type: research
Conclusion: Fungal presence and A. fumigatus are detectable by qPCR in patient BAL. Systemically patients displayed varying degrees of antibody reactivity to Aspergillus. Fungal presence significantly correlated with plasma and BAL cytokines indicating an active immune reaction. Further studies are required to assess the role of Aspergillus and other fungal species within the asthmatic lung.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Clinical Problems Source Type: research
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