Differential behavioral and glial responses induced by dopaminergic mechanisms in the iNOS knockout mice.

Differential behavioral and glial responses induced by dopaminergic mechanisms in the iNOS knockout mice.
Behav Brain Res. 2018 May 08;:
Authors: Issy AC, Nascimento GC, de Abreu GHD, Tristão FS, Del-Bel E, Duarte T, Bortolanza M
Abstract
The interaction between distinctive nitric oxide synthase (NOS) isoforms and the dopamine system provides new avenues to the development of pharmacological tools for the pathophysiological conditions of the dopaminergic system. Our aim was to investigate the influences of dopamine-induced effects in inducible NOS knockout (iNOS KO) mice. In order to characterize iNOS KO mice phenotype, the animals were submitted to the basal analyses of motor, sensorimotor and sensorial abilities. Pharmacological challenging of the dopaminergic system included the investigation of amphetamine-induced prepulse inhibition (PPI) disruption, haloperidol-induced catalepsy, reserpine-induced oral involuntary movements and hyperlocomotion induced by amphetamine in reserpine treated mice. The iNOS KO mice showed significant reduction of spontaneous motor activity, but there was no significant difference in sensorimotor or sensorial responses of iNOS KO mice compared to wild type (WT). Regarding the dopaminergic system, iNOS KO mice showed a significant increase of haloperidol-induced catalepsy. This effect was confirmed through an iNOS pharmacological inhibitor (1400 W) in WT mice. In addition, iNOS KO reserpine treated ...

Source: Behavioural Brain Research - May 8, 2018 Category: Neurology Authors: Issy AC, Nascimento GC, de Abreu GHD, Tristão FS, Del-Bel E, Duarte T, Bortolanza M Tags: Behav Brain Res Source Type: research