Inhibition of glutamate oxaloacetate transaminase 1 in cancer cell lines results in altered metabolism with increased dependency of glucose

Glutamate oxaloacetate transaminase 1 (GOT1) regulates cellular metabolism through coordinating the utilization of carbohydrates and amino acids to meet nutrient requirements. KRAS mutated cancer cells were re...

Source: BMC Cancer - May 11, 2018 Category: Cancer & Oncology Authors: Xiaoshan Zhou, Sophie Curbo, Fuqiang Li, Shuba Krishnan and Anna Karlsson Tags: Research article Source Type: research