Treatment of rat congenital diaphragmatic hernia with sildenafil and NS-304, selexipag's active compound, at the pseudoglandular stage improves lung vasculature.

In conclusion, antenatal treatment with sildenafil improved airway morphogenesis and pulmonary vascular development, while selexipag only acted positively on pulmonary vascular development. The combination of both compounds did not act synergistically, probably because of a decreased efficiency of both compounds caused by CYP interaction and induction. These new insights create important possibilities for future treatment of pulmonary vascular abnormalities in CDH patients already in the antenatal period of life.
PMID: 29745254 [PubMed - as supplied by publisher]

Source: Am J Physiol Lung Ce... - May 10, 2018 Category: Respiratory Medicine Authors: Mous DS, Kool HM, Burgisser PE, Buscop-van Kempen MJ, Nagata K, Boerema-de Munck A, van Rosmalen J, Dzyubachyk O, Wijnen RM, Tibboel D, Rottier RJ Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research