Reverse iontophoretic extraction of gabapentin: a mechanistic study.

Reverse iontophoretic extraction of gabapentin: a mechanistic study. Curr Drug Deliv. 2018 May 03;: Authors: Chakrabarty S, Ghosh B, Giri TK, Khanam J Abstract The work was aimed at extracting gabapentin by transdermal reverse iontophoresis to check its feasibility for noninvasive therapeutic drug monitoring. Gabapentin was delivered in phosphate buffer (pH 7.4) at a therapeutic concentration range of 2-10 µg/ml. The same media was also used in receiver compartment. Extractions were carried out under an electric field of 5 V (current intensity range 0.3 mA/cm2-0.5 mA/cm2), provided by a custom-made power source for a period of 4 h. Samples were withdrawn at hourly intervals and drug content was analyzed by HPLC. Parameters studied were effect of donor concentration, donor pH and current intensity. Results indicated that gabapentin extraction occurred at both anode and cathode with cathodal extractions showing higher value at all concentrations. Extraction rates at both the chambers were affected by time, the first hour extraction was notably higher than the later hours. Highest extraction rate was noted at pH 5. Surprisingly, anodal extraction was found to show greater positive correlation with current intensity compared to cathodal extraction. As gabapentin carried no net charge at pH 7.4, orientation mediated electromigration was suggested to be the cause. PMID: 29732968 [PubMed - as supplied by publisher]
Source: Epilepsy Curr - Category: Neurology Authors: Tags: Curr Drug Deliv Source Type: research