Non-HDL as a Valid Surrogate Marker of Small Dense LDL in a Young Indian Population

This study aimed at identifying non-HDL as a superior surrogate marker of sdLDL cholesterol in a young Indian population. 161 healthy subjects  <  45 years were tested for lipid profile, apolipoproteins A1 and B, and sdLDL particle size. sdLDL particles showed negative correlation with non-HDL (r = − 0.283,p <  0.001), LDL (r = − 0.195,p = 0.013) and apoB/apo A1 (r = − 0.175,p = 0.026), the significance being greatest with non-HDL. ROC showed AUC for non-HDL, LDL and apoB/apo A1 as 0.704, 0.686, and 0.596 respectively. For LDL <  130 mg/dL, sdLDL showed a more significant negative correlation with non-HDL (r = − 0.291,p <  0.001) as compared with apoB/apoA1 (r = − 0.172,p = 0.037). For triglycerides <  200 mg/dL, sdLDL particle size showed higher significant negative correlation with non-HDL (r = − 0.213,p = 0.015) than with LDL (r = − 0.176,p = 0.045) while for triglycerides between 200 and 400 mg/dL, significant negative correlation was observed only with non-HDL (r = − 0.372,p = 0.043). Hence, our study suggested that non-HDL is a superior surrogate marker of sdLDL particle size as compared to LDL and apoB/A1 ratio in a young healthy Indian population and should be used for optimum assessment of dyslipidemias and CAD risk.
Source: Indian Journal of Clinical Biochemistry - Category: Biochemistry Source Type: research