Feasibility Study of Human Corneal Endothelial Cell Transplantation Using an In Vitro Human Corneal Model

Conclusions: Direct transplantation of cultured human CE cells and immortalized HCEC-12 to bare posterior corneal stroma resulted in formation of an endothelial monolayer and restoration of stromal hydration to physiological thickness, demonstrating the feasibility of cell therapy in treatment of CE decompensation in a human in vitro model.
Source: Cornea - Category: Opthalmology Tags: Basic Investigation Source Type: research

Related Links:

Abstract PURPOSE: Chronic ocular graft-versus-host disease (GVHD) is a long-term complication after hematopoietic stem cell transplantation (HSCT) and leads to irreversible visual morbidity due to severe ocular surface impairments including visual disfunction. However, knowledge about the optical function in chronic ocular GVHD is limited because it is difficult to assess quantitative optical function objectively. The development of anterior segment optical coherence tomography has allowed objective quantification of optical function by evaluating corneal higher-order aberrations (HOAs). Therefore, we applied this...
Source: The Ocular Surface - Category: Opthalmology Authors: Tags: Ocul Surf Source Type: research
CorneaGen focuses on innovating technologies to cure corneal blindness by 2040 and provides donor tissues for cornea transplants.
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
Purpose: To compare the outcomes between mini-simple limbal epithelial transplantation (mini-SLET) and conjunctival autograft (CAG) fixation with fibrin glue after excision of pterygium. Methods: Ninety-two eyes with primary nasal pterygium were prospectively randomized into a CAG control arm and a mini-SLET study arm. Follow-up examinations were set at the first and third day, at weeks 1, 2, and 4, and at the third and sixth month after surgery. The primary outcome measure was the recurrence rate at 1, 3, and 6 months after surgery, whereas the secondary outcome measures were the intraoperative time, postoperative sy...
Source: Cornea - Category: Opthalmology Tags: Clinical Science Source Type: research
Purpose: To describe the evolution of best spectacle-corrected visual acuity (BSCVA) after Descemet stripping automated endothelial keratoplasty (DSAEK) for very advanced pseudophakic bullous keratopathy (PBK) and to determine whether the thickness of corneal grafts in DSAEK surgery for advanced PBK correlates with BSCVA 6 months postoperatively. Methods: In a prospective, single-center, observational study, 141 eyes treated with DSAEK surgery were studied, from patients requiring posterior lamellar transplantation for advanced PBK. Graft thickness was measured during the surgery and in vivo 6 months later. The primar...
Source: Cornea - Category: Opthalmology Tags: Clinical Science Source Type: research
Purpose: To investigate the relationship between corneal collagen cross-linking (CXL) and the number of corneal transplants required for the treatment of keratoconus (KCN) in 2 major Canadian provinces. Methods: This is a retrospective review of all corneal transplantation performed in Ontario and British Columbia over an 18-year period (1998–2016). Data were collected at the Eye Bank of Canada—Ontario/British Columbia Divisions. The primary outcome was to determine the change in proportion and absolute number of corneal transplants required for treatment of KCN since the introduction of CXL in Canada in 2...
Source: Cornea - Category: Opthalmology Tags: Clinical Science Source Type: research
Conclusions: Cenegermin was effective in restoring corneal integrity in this pediatric patient with NK.
Source: Cornea - Category: Opthalmology Tags: Case Report Source Type: research
CONCLUSIONS: Presence of a GDD adversely affects graft survival whereas glaucomatous eyes which were medically managed or surgically managed without a GDD had survival rates comparable to controls. Glaucoma-filtering surgeries may confer graft survival advantage over tube shunt surgeries after DSEK. PMID: 31564348 [PubMed - in process]
Source: Canadian Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Can J Ophthalmol Source Type: research
CONCLUSION: This study provides additional evidence for the long-term safety of donor eyes when providing limbal stem cell tissue for CLAU or CLAL. PMID: 31564346 [PubMed - in process]
Source: Canadian Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Can J Ophthalmol Source Type: research
Culture and characterization of human dental pulp‑derived stem cells as limbal stem cells for corneal damage repair. Mol Med Rep. 2019 Sep 19;: Authors: Patil S, D'Souza C, Patil P, Patil V, Prabhu M, Bargale A, Kaveeshwar V, Kumar S, Shetty P Abstract Limbal stem cell deficiency (LSCD) is one of the leading causes of corneal damage. Injury or inflammation in the cornea causes LSCD, which may be unilateral or bilateral depending upon the cause. Limbal epithelial cell implants successfully improve vision in patients with chemical injury‑induced LSCD. Transplantation of cultured epithelial stem cells...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
(MANCHESTER, N.H.) — A woman who was severely burned in a domestic violence attack in Vermont is hoping for a second face transplant after doctors recently discovered tissue damage that likely will lead to the loss of her donor face. Carmen Blandin Tarleton, 51, was burned over 80% of her body when her estranged husband beat her with a baseball bat and doused her body with lye in 2007. Six years ago, she received a face transplant at Brigham and Woman’s Hospital in Boston, where she’s being evaluated for a possible second transplant. Tarleton, who now lives in Manchester, New Hampshire, told The Boston Gl...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized new hampshire onetime Surgery Source Type: news
More News: Corneal Transplant | Study | Transplants