Daily aspirin linked to higher risk in men

Men who take once-daily aspirin have nearly double the risk of melanoma compared to men who are not exposed to daily aspirin, reports a new Northwestern Medicine study. Women, however, do not have an increased risk in this large patient population. The study was published April 27 in the Journal of the American Academy of Dermatology.
Source: World Pharma News - Category: Pharmaceuticals Tags: Featured Research Research and Development Source Type: news

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Publication date: Available online 22 May 2019Source: Urology Case ReportsAuthor(s): K. Sawaleim, M.Z. Mehdi, A.H. Ansari, A.M.S. RamadanAbstractMelanosis of the bladder, also known as melanosis vesicae, refers to presence of pigment in bladder mucosa. A rare phenomenon, however, it can be confused with the primary or metastatic melanoma of the bladder. Therefore, knowledge of the entity can prevent over diagnosis of this benign entity.We are reporting a case of melanosis of bladder in a 69 year old male with prolonged history of LUTS and bladder diverticulae. Cystoscopic examination showed black patches and biopsy reveale...
Source: Urology Case Reports - Category: Urology & Nephrology Source Type: research
Publication date: Available online 22 May 2019Source: Pathology - Research and PracticeAuthor(s): Hui Wang, Chaturika HerathABSTRACTSignet ring cell mesothelioma is a rare variant of epithelioid mesothelioma with limited cases published. It has a male predilection and most commonly occurs on pleura; it can also arise in the peritoneal cavity. The signet ring cell morphology can pose a challenge leading to a potential diagnostic error. A variety of benign and malignant diseases, including reactive histiocytic hyperplasia, adenocarcinoma, melanoma, and lymphoma with signet ring cell morphology should be considered in the dif...
Source: Pathology Research and Practice - Category: Pathology Source Type: research
Conclusion: The BHDS can be associated with tumors of the skin and kidney. In this case, we noted ocular melanocytosis, malignant choroidal melanoma, and bilateral pinpoint retinal pigment epithelial detachments.
Source: Retinal Cases and Brief Reports - Category: Opthalmology Tags: Case Report Source Type: research
Discussion: In addition to the widely known class-related retinal toxicity, MEK and BRAF inhibitor-associated adverse events may also involve the optic nerve head, causing visual field defects probably regressing spontaneously after discontinuation of targeted oncologic therapy. In such cases, repeat brain imaging and exclusion of melanoma-associated retinopathy is recommended. Reinitiation of treatment and subsequent dose escalation seem to be feasible, but should be monitored by an ophthalmologist.
Source: Retinal Cases and Brief Reports - Category: Opthalmology Tags: Case Report Source Type: research
Publication date: Available online 23 May 2019Source: Computers in Human BehaviorAuthor(s): Robin L. Nabi, Richard Huskey, Spencer B. Nicholls, Lauren Keblusek, Megan ReedAbstractCouched within the self-effects paradigm of social media influence, this research examines how posting a health promotion message to one’s social media influences one’s own, versus others’, later health behaviors, with emphasis on emotional intensity and message sharing directives. 382 participants viewed one of eight versions of a melanoma awareness video and were given the opportunity to post it to their Facebook page. Video sh...
Source: Computers in Human Behavior - Category: Information Technology Source Type: research
In this study, in vitro and animal models were used to explore the effect of DLN combined with miR‑21 inhibitor on melanoma cells. The data demonstrated that treatment with 5 µl DLN (final concentration of doxorubicin 5 mg/ml) for 72 h effectively inhibited melanoma cell growth (~75% inhibition). The experiments were then divided into five groups: Control group, vector group, DLN group, miR‑21 inhibitor group and miR‑21 inhibitor + DLN group. Compared with the control group, DLN (5 µl) or miR‑21 inhibitor significantly reduced migration and invasion of melanoma cells, promoted apoptosis and arrested cel...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Intratumoral injection of dendritic cells overexpressing interleukin‑12 inhibits melanoma growth. Oncol Rep. 2019 May 21;: Authors: Yao W, Li Y, Zeng L, Zhang X, Zhou Z, Zheng M, Wan H Abstract The present study aimed to investigate the antitumor effects of an intratumoral injection of dendritic cells (DCs) overexpressing interleukin-12 (IL‑12) on melanoma. DCs, isolated from mouse spleen, were gene‑modified using an IL‑12 overexpression vector. Melanoma B6 cells were injected into C57BL/6 mice to generate tumors. Thereafter, DCs overexpressing IL‑12 were injected into the tumors, and tumor v...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Authors: Olszanski AJ Abstract According to Dr. Anthony J. Olszanski, the most significant updates to the treatment of cutaneous melanoma include the recently published results of MSLT-II, which demonstrated that ultrasound-guided follow-up can be performed rather than a complete lymph node dissection, improving morbidity in patients with sentinel node metastases while not adversely affecting survival. In the adjuvant setting, the PD-1 inhibitors nivolumab and pembrolizumab are now FDA-approved, in addition to dabrafenib and trametinib, for patients with BRAF mutations. PMID: 31117032 [PubMed - in process]
Source: Journal of the National Comprehensive Cancer Network : JNCCN - Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research
We report a patient who presented with cranial neuropathy related to a malignant skull base lesion that originated as lentigo maligna. The diagnosis was challenging, requiring two surgeries to obtain tissue and neither biopsy leading to a definitive diagnosis. Pathological analyses demonstrated positive immunoreactivity for SOX10 and S100, preservation of H3K27me3, and PTEN and STK11 mutations. The patient was managed with Gamma Knife Radiosurgery and combination immunotherapy. Imaging at 9 months post-SRS showed resolution of the mass lesion. Clinically, the patient has occasional left-sided facial pain requiring no medic...
Source: Practical Radiation Oncology - Category: Cancer & Oncology Source Type: research
Researchers studied whether risk factors differ for  early-stage melanoma metastasis via the lymphatic system and the bloodstream.
Source: CancerNetwork - Category: Cancer & Oncology Source Type: news
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