The role of autophagy in acute brain injury: A state of flux?

The role of autophagy in acute brain injury: A state of flux?
Neurobiol Dis. 2018 Apr 25;:
Authors: Wolf MS, Bayır H, Kochanek PM, Clark RSB
Abstract
It is established that increased autophagy is readily detectable after various types of acute brain injury, including trauma, focal and global cerebral ischemia. What remains controversial, however, is whether this heightened detection of autophagy in brain represents a homeostatic or pathologic process, or an epiphenomenon. The ultimate role of autophagy after acute brain injury likely depends upon: (Galluzzi et al., 2016) the degree of brain injury and the overall autophagic burden; (Smith et al., 2011) the capacity of individual cell types to ramp up autophagic flux; (Mizushima et al., 2004) the local redox state and signaling of parallel cell death pathways; (Boland and Nixon, 2006) the capacity to eliminate damage associated molecular patterns and toxic proteins and metabolites both intra- and extracellularly; and (Su et al., 2017) the timing of the pro- or anti-autophagic intervention. In this review, we attempt to reconcile conflicting studies that support both a beneficial and detrimental role for autophagy in models of acute brain injury.
PMID: 29704549 [PubMed - as supplied by publisher]

Source: Neurobiology of Disease - April 25, 2018 Category: Neurology Authors: Wolf MS, Bayır H, Kochanek PM, Clark RSB Tags: Neurobiol Dis Source Type: research