A systematic review and meta-analysis of the probiotics and synbiotics effects on oxidative stress

Publication date: July 2018 Source:Journal of Functional Foods, Volume 46 Author(s): Javad Heshmati, Farnaz Farsi, Fatemeh Shokri, Mahroo Rezaeinejad, Amir Almasi-Hashiani, Samira Vesali, Mahdi Sepidarkish We performed a comprehensive search of medical bibliographic databases to identify interventional studies reporting the effect of probiotics (or synbiotics) supplementation on biomarkers of oxidative stress. Twenty seven articles that included 1363 subjects (709 cases and 699 controls) were included to our analyses. Oxidative stress parameters levels, including total antioxidant capacity (TAC) (0.31 mmol/L, 95% CI: 0.13–0.50, P < 0.001), glutathione (GSH) (SMD: 0.44 μmol/L, 95% CI: 0.26–0.62, P < 0.001), superoxide dismutase (SOD) (SMD: 0.48 U/mg, 95% CI: 0.16–0.81, P = 0.004) and nitric oxide (NO) (SMD: 0.57 μmol/L, 95% CI: 0.19–0.94, P = 0.003) were higher in probiotics (or synbiotics) group compared to controls. Moreover, malondialdehyde (MDA) (SMD = −0.45 μmol/L, 95%CI = −0.63 to −0.26, P < 0.001) level was lower than controls. Probiotics and synbiotic supplementation improve antioxidant resistance and increase the amount of antioxidant enzymes in the body. Graphical abstract
Source: Journal of Functional Foods - Category: Nutrition Source Type: research