Abundance of ribosomal RNA gene copies in the genomes of schizophrenia patients

The ribosome is a critical component of the translation machinery. The key component of ribosomes is ribosomal RNA (rRNA). Dysregulation of rRNA biogenesis has been implicated in some human diseases. One of the factors affecting rRNA biogenesis is the ribosomal RNA genes (rDNA) copy number in the genome. The aim of this study was to examine the rDNA copy number (CN) variation in the genomes of patients with schizophrenia (SZ) compared to healthy controls (HC).

Source: Schizophrenia Research - January 11, 2018 Category: Psychiatry Authors: I.V. Chestkov, E.M. Jestkova, E.S. Ershova, V.E. Golimbet, T.V. Lezheiko, N.Y. Kolesina, L.N. Porokhovnik, N.A. Lyapunova, V.L. Izhevskaya, S.I. Kutsev, N.N. Veiko, S.V. Kostyuk Source Type: research