Solubility determination of raloxifene hydrochloride in ten pure solvents at various temperatures: Thermodynamics-based analysis and solute –solvent interactions

Publication date: 10 June 2018 Source:International Journal of Pharmaceutics, Volume 544, Issue 1 Author(s): Abdul Ahad, Faiyaz Shakeel, Omar Ali Alfaifi, Mohammad Raish, Ajaz Ahmad, Fahad I. Al-Jenoobi, Abdullah M. Al-Mohizea The purpose of the present study was to determine the solubility of raloxifene hydrochloride (RHCl) in ten solvents: water, ethanol, isopropyl alcohol (IPA), ethylene glycol (EG), propylene glycol (PG), polyethylene glycol-400 (PEG-400), Transcutol, 1-butanol, dimethyl sulfoxide (DMSO), and ethyl acetate (EA) at temperatures of 298.2–323.2 K and a pressure of 0.1 MPa. The solubility data obtained was fitted upon “Apelblat and Van't Hoff” equations. The maximum mole fraction solubility of RHCl was obtained in DMSO (5.02 × 10−2 at 323.2 K), followed by PEG-400 (5.92 × 10−3 at 323.2 K), EA (3.11 × 10−3 at 323.2 K), Transcutol (1.22 × 10−3 at 323.2 K), PG (2.19 × 10−4 at 323.2 K), 1-butanol (1.96 × 10−4 at 323.2 K), IPA (1.47 × 10−4 at 323.2 K), ethanol (7.90 × 10−5 at 323.2 K), EG (6.65 × 10−5 at 323.2 K), and water (3.60 × 10−5 at 323.2 K). Similar fashions were noticed at each studied temperature. The higher solubility of RHCl in DMSO, PEG-400, EA, and Transcutol was possibly referable to their lower polarity in comparison with water. The molecular interactions between the solute and solvent molecules were estimated by calculating parameters like ...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research