Identification of subsets of actionable genetic alterations in KRAS-mutant lung cancers using association rule mining

ConclusionsI identified several genes that are co-mutated in primary KRAS-mutant lung cancer samples. I also identified subpopulations of KRAS-mutant lung cancers based on sets of genes that were co-mutated. Pre-clinical models that capture these subsets of KRAS-mutant tumors may enhance our understanding of lung cancer development and, in addition, facilitate the design of personalized treatment strategies for lung cancer patients carrying KRAS mutations.
Source: Cellular Oncology - Category: Cancer & Oncology Source Type: research