Healthy Diet, Healthy Eyes

THURSDAY, April 20, 2018 -- Healthy eating may help preserve your vision as you age, eye experts say. Age-related macular degeneration (AMD) damages the macula (a small area near the center of the retina, located on the inside back layer of the...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news

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AbstractAberrant growth of blood vessels in the choroid layer of the eye, termed choroidal neovascularization (CNV), is the pathological hallmark of exudative age-related macular degeneration (AMD), causing irreversible blindness among the elderly. Co-localization of proangiogenic factors and hypoxia inducible factors (HIF) in neovascular membranes from AMD eyes suggests the role of hypoxia in pathogenesis of CNV. In order to utilize hypoxic conditions in RPE for therapeutic purposes, we developed an optimized hypoxia regulated, RPE cell-specific gene therapy to inhibit choroidal neovascularization. An adeno-associated vir...
Source: Journal of Molecular Medicine - Category: Molecular Biology Source Type: research
Patients with age-related macular degeneration, diabetic retinopathy or glaucoma had a 40 to 50 percent greater risk of Alzheimer's disease than those without the eye conditions, the authors of a new study report.
Source: WebMD Health - Category: Consumer Health News Source Type: news
Authors: Lashgari A, Kabiri M, Ramezani A, Entezari M, Karimi S, Kakaei S, Yaseri M, Nikkhah H Abstract Purpose: To determine the prognostic factors and visual and anatomic outcomes of pars plana vitrectomy (PPV) in patients with dropped nucleus following complicated phacoemulsification (PE). Methods: The records of patients with complicated PE who underwent PPV to remove posteriorly dislocated nucleus fragments from January 2011 to December 2014 were retrospectively reviewed. Results: Of 43 patients, 36 patients (36 eyes) were included with mean age of 73 ± 9.5 years and mean follow-up duration of 2...
Source: Journal of Ophthalmic and Vision Research - Category: Opthalmology Tags: J Ophthalmic Vis Res Source Type: research
The anti-impotence drug may stop age-related macular degeneration.   This follows a two-year trial led at Columbia University in New York. The condition is the UK’s leading cause of blindness.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Conclusions: The expression of the C9 gene in cultured RPE cells is highly induced by extracellular hyperosmolarity, hypoxia, and oxidative stress. The data may support the assumption that C9 gene expression may stimulate the expression of inflammatory (NLRP3) and angiogenic growth factors (VEGF) in RPE cells. Extracellular C9 protein may attenuate this effect, in part via negative regulation of the C9 mRNA level. PMID: 30090015 [PubMed - in process]
Source: Molecular Vision - Category: Molecular Biology Tags: Mol Vis Source Type: research
Authors: Seibel I, Nürnberg D, Löwen J, Winterhalter S, Zeitz O, Joussen AM Abstract PEHCR (peripheral exudative haemorrhagic chorioretinopathy) is a disease manifested clinically, particularly by subretinal bleeding, retinal exudates, retinal pigment epithelium detachments (RPE detachments), exudative retinal detachment and sub-RPE bleeding. The PEHCR lesion is often characterized by its polypoidal pattern, which is very similar to PCV (polypoidal choroidal vasculopathy) polyps. Diagnosis is best made with a wide-field ICGA (indocyanine green angiography). In approximately half of patients, macular chang...
Source: Klinische Monatsblatter fur Augenheilkunde - Category: Opthalmology Tags: Klin Monbl Augenheilkd Source Type: research
CONCLUSIONS: The prevalence of PCV is higher among Japanese subjects than Caucasians in Western countries. Male gender and smoking habit were significant risk factors for PCV in a general Japanese population. PMID: 30084710 [PubMed - as supplied by publisher]
Source: Seminars in Ophthalmology - Category: Opthalmology Tags: Semin Ophthalmol Source Type: research
Publication date: Available online 8 August 2018Source: Alzheimer's &DementiaAuthor(s): Cecilia S. Lee, Eric B. Larson, Laura E. Gibbons, Aaron Y. Lee, Susan M. McCurry, James D. Bowen, Wayne C. McCormick, Paul K. CraneAbstractIntroductionIdentifying ophthalmic diseases associated with increased risk of Alzheimer's disease (AD) may enable better screening and understanding of those at risk of AD.MethodsDiagnoses of glaucoma, age-related macular degeneration (AMD), and diabetic retinopathy (DR) were based on International Classification of Diseases, 9th revision, codes for 3877 participants from the Adult Changes in Tho...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
(University of Washington Health Sciences/UW Medicine) A study of 3,877 randomly selected patients found a significant link between three degenerative eye diseases -- age-related macular degeneration, diabetic retinopathy and glaucoma -- and Alzheimer' disease.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Publication date: Available online 7 August 2018Source: Journal of Theoretical BiologyAuthor(s): Mariia Dvoriashyna, Alexander J.E. Foss, Eamonn A. Gaffney, Oliver E. Jensen, Rodolfo RepettoAbstractThe retinal pigment epithelium (RPE) is the outermost cell layer of the retina. It has several important physiological functions, among which is removal of excess fluid from the sub-retinal space by pumping it isotonically towards the choroid. Failure of this pumping leads to fluid accumulation, which is closely associated with several pathological conditions, such as age-related macular degeneration, macular oedema and retinal ...
Source: Journal of Theoretical Biology - Category: Biology Source Type: research
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