206 Elucidating novel pathways of genomic instability and the activation of meiomitotic programmes in cutaneous T cell lymphoma

Cutaneous T-Cell Lymphomas (CTCL) exhibit an aggressive form of genomic instability resulting in chromosomal aberrations that ultimately drive cancer development and progression. Despite their role in carcinogenesis, their molecular pathogenesis remains poorly understood. A recent study shows that cancer testis (CT) antigens are found to be ectopically expressed in CTCL and a variety of cancers, begging the question if meiomitosis, a process when daughter cells inherit the partial expression of meiotic machinery following mitosis, contributes to increased genomic instability.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Carcinogenesis and Cancer Genetics Source Type: research