229 Tumor surveillance: Alterations in Xeroderma Pigmentosum?

Xeroderma pigmentosum is a rare genetic disease characterized by a severe susceptibility to cutaneous cancers (CC). This disease is due to defective nucleotide excision repair of DNA lesions occurring upon solar radiation. XP patients are prone to particularly aggressive CC as compared to the general population. Evidence supports the role of the activation of tumor microenvironment by cancer cells, notably on dermal fibroblasts that, in turn, fuel the growth of aggressive cancers. We hypothesized that XP fibroblasts could influence cancer types in XP patients.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Carcinogenesis and Cancer Genetics Source Type: research