1203 AIM2-deficient dendritic cell vaccination improves adoptive T-cell therapy via the activation of type I IFN signaling through STING

Tumor-derived, cytosolic DNA has been reported to stimulate the production of type I interferon (IFN) through a STING-dependent signaling pathway in dendritic cells (DCs), which helps to initiate a spontaneous T cell response against melanoma. However, cytosolic DNA can also be recognized by AIM2, a cytosolic innate immune sensor, whose function in melanoma remains unclear. To determine the role of AIM2 in melanoma microenvironment, we subcutaneously challenged Aim2/ mice with B16F10 melanoma. Surprisingly, these mice exhibited a lower tumor burden with fewer tumor-infiltrating regulatory T cells (Tregs) than WT mice, indicating that AIM2 exerts an immunosuppressive effect.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Pigmentation and Melanoma Source Type: research