The Effect of Aliskiren on Exercise Capacity in Older Patients with Heart Failure and Preserved Ejection Fraction: A Randomized, Placebo-Controlled, Double-Blind Trial

Publication date: Available online 4 April 2018 Source:American Heart Journal Author(s): Bharathi Upadhya, Peter H. Brubaker, Timothy M. Morgan, Joel D Eggebeen, Geoffrey T. Jao, Kathryn P. Stewart, Dalane W. Kitzman In older patients (70±7years) with chronic well-compensated heart failure with preserved ejection and controlled blood pressure, 6months treatment with aliskiren (direct renin inhibitor) showed non-significant trends for modest improvements in peak exercise oxygen consumption (14.9±0.2ml/kg/min versus 14.4±0.2ml/kg/min; P =.10, trend) and ventilatory anaerobic threshold (888±19m//min versus 841±18ml/min; P =.08).
Source: American Heart Journal - Category: Cardiology Source Type: research