Mp64-08 a novel biguanide derivative drug, im176, inhibits prostate cancer
Biguanides were originally developed for the treatment of hyperglycemia and type 2 diabetes mellitus. Recently, the biguanides metformin and phenformin have been shown to exert potential anticancer effects in prostate cancer. We evaluated the anti-cancer efficacy and mechanism of IM176, a novel biguanide derivate drug on prostate cancer using prostate cancer cell lines and patient-derived castration-resistant prostate cancer cell lines.
Source: The Journal of Urology - Category: Urology & Nephrology Authors: Choung-Soo KIM, Wonseok Choi, YOONRIM KIM, Bong-Min Kim Tags: Prostate Cancer: Basic Research & Pathophysiology II Source Type: research
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