Late presentation of subtotal C6 deficiency in a patient with recurrent Neisseria meningitides infections

The complement system is important in fighting meningococcal disease. Recurrent meningococcal infections are a significant feature of terminal complement deficiency.1 The terminal complement system produces a membrane attack complex (MAC), which creates pores in bacteria, leading to lysis of microorganisms. Most invasive meningococcal infections are caused by Neisseria serotypes A, B, C, W-135, and Y, all of which are targeted with commercially available vaccines. Infections with less common serotypes are seen in patients with terminal complement deficiencies.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Source Type: research

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Shanshan Zhang1, Dongli Yuan2 and Ge Tan1* 1Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China 2The Institute of Medical Information, Chongqing Medical University, Chongqing, China Primary systemic vasculitis can affect every structure in both the central and peripheral nervous system, causing varied neurological manifestations of neurological dysfunction. Early recognition of the underlying causes of the neurological symptoms can facilitate timely treatment and improve the prognosis. This review highlights the clinical manifestations of primary systemic vasc...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Common Variable Immune Deficiency (CVID) can present with a range of organ system involvement, including normal number of B-cells but decreased IgG, eventual decline in IgA and/or IgM, and poor/absent response to vaccinations.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: M273 Source Type: research
Two serogroup B meningococcal (MenB) vaccines, MenB-FHbp and MenB-4C, are available for use in persons aged 10-25 years in the United States. The Advisory Committee on Immunization Practices (ACIP) recommends either three-dose series of MenB-FHbp or two-dose series of MenB-4C. Adverse reactions like anaphylaxis have been infrequently reported.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Source Type: research
Despite routine immunization with pneumococcal conjugate vaccines, Streptococcus pneumoniae is still a significant cause of bacteremia, pneumonia and meningitis. Osteoarticular pneumococcal infections are very rare, accounting for less than 5% of all invasive pneumococcal diseases (IPD).
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Source Type: research
Conclusions: Residential proximity to road traffic volumes and traffic density were associated with increased all-cause mortality in patients undergoing treatment for active tuberculosis even after adjusting for multiple demographic, socioeconomic, and clinical factors, suggesting that TB patients are susceptible to the adverse health effects of traffic-related air pollution. https://doi.org/10.1289/EHP1699 Received: 31 January 2017 Revised: 18 August 2017 Accepted: 23 August 2017 Published: 29 September 2017 Address correspondence to R.J. Blount, Divisions of Pulmonary and Critical Care Medicine and Pediatric Pulmon...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
Questions have recently been raised by regulatory bodies in the United States regarding a potential risk of infections related to subcutaneous allergen immunotherapy (SCIT) injections. In response to a fungal meningitis outbreak from contaminated, compounded injectable medications, the US Food and Drug Administration endorsed the US Pharmacopeia's Pharmaceutical Compounding —Sterility Preparations guidelines as the standard for pharmaceutical compounding in 2013.1 An exemption was granted to allergen extracts as long as they addressed specific procedures that were feasible in an office setting.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Letter Source Type: research
Discussion Regurgitation is a passive expulsion of ingested material out of the mouth. It is a normal part of digestion for ruminants such as cows and camels. Nausea is an unpleasant abdominal perception that the person may describe as feeling ill to the stomach, or feeling like he/she is going to vomit. Anorexia is frequently observed. Nausea is usually associated with decreased stomach activity and motility in the small intestine. Parasympathetic activity may be increased causing pale skin, sweating, hypersalivation and possible vasovagal syndrome (hypotension and bradycardia). Retching or dry heaves is when there are sp...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
The approval of first-of-a-kind drugs rose last year to forty-one, resulting in the highest level of newly approved U.S. drugs in nineteen years. The total number of new drugs approved last year was even higher at sixty-nine. The rising figures reflect an industry-wide desire to research and develop drugs for rare and hard-to-treat diseases. The newly approved drugs serve to advance medical care and the health of patients suffering from many ailments, including various forms of cancer, heart failure, and cystic fibrosis. Additionally, more than 40% of the new therapies were approved for treatment of rare or "orphan&...
Source: Policy and Medicine - Category: American Health Authors: Source Type: blogs
Conclusion We leave you with words from Robin: “My family and I hope that Holly’s story will make a difference and help you realize that you must be aware of the risks of vaccinations, just as you make yourself aware of the risks of any medical procedure. We hope to make change, and one very important improvement must be that the pediatricians acknowledge that there are vaccine reactions, that moderate to serious and even fatal vaccine reactions do exist and occur at least 100 times more than is reported to the Vaccine Adverse Event Reporting System (VAERS).  We are still very disappointed and disgusted wi...
Source: vactruth.com - Category: Allergy & Immunology Authors: Tags: Augustina Ursino Human Top Stories adverse reactions Holly Marie Stavola Holly's Law MMR vaccine National Vaccine Injury Compensation Program (NVICP) Robin Stavola truth about vaccines Vaccine Death VAERS Source Type: blogs
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