[TECHNIQUE] Phylogenetic Quantification of Intratumor Heterogeneity

We describe how multiple samples can guide tree inference through accurate phasing of germline variants and copy-number profiles. We show their relevance in detecting clonal expansions and deriving summary statistics quantifying the overall degree of ITH, and discuss how the relationship of metastatic clades might give us insight into the dominant mode of cancer progression. We further outline how multisample studies might help us better understand selective processes acting on cancer genomes and help to detect neutral evolution and mutator phenotypes.
Source: Cold Spring Harbor perspectives in medicine - Category: Research Authors: Tags: Cancer Evolution TECHNIQUE Source Type: research