O6.5. linking cortical and connectional pathology in schizophrenia

DiscussionCortical thinning and breakdown in white matter anisotropy are inversely related in young schizophrenia patients, with abnormally elevated white matter myelination found adjacent to frontal regions with extensive cortical thinning. We argue that elevated frontal anisotropy reflects regionally-specific, compensatory responses to cortical thinning, which are eventually overwhelmed with increasing illness duration.
Source: Schizophrenia Bulletin - Category: Psychiatry Source Type: research