S6-4. CIDP syndrome with anti-NF155 and -CNTN1 IgG4 antibodies

In recent years, the specific autoantibodies for some CIDP patients groups have been found. Neurofascin155 (NF155) and contactin-1 (CNTN1), which are adhesion molecules at paranodal axo-glial junction, are the novel target antigens. The patients with anti-NF155 and-CNTN1 IgG4 antibodies might form specific clinical subgroups. In 2013, Querol et al. found anti-CNTN1 IgG4 antibodies in 3 of 46 patients with CIDP. Subsequent studies showed the positivity rate of anti-CNTN1 IgG4 antibodies in CIDP as 2.4 –7.5%.

Source: Clinical Neurophysiology - March 30, 2018 Category: Neuroscience Authors: Norito Kokubun Source Type: research