The NC domain of HIV-1 Gag contributes to the interaction of Gag with TSG101

Conclusion The NC zinc fingers and p6 domain of Gag participate in the formation of the Gag-TSG101 complex and in its cellular localisation. General significance This study illustrates that the NC and p6 domains cooperate in the interaction with TSG101 during HIV-1 budding. In addition, details on the Gag-TSG101 complex were obtained by combining two high resolution biophysical techniques.

Source: Biochimica et Biophysica Acta (BBA) General Subjects - March 28, 2018 Category: Biochemistry Source Type: research