Hospitals 'failing' on genetic bowel cancer test
A charity says that more than 80% are failing to test for the genetic condition Lynch syndrome.
Abstract Colorectal cancer (CRC) is common with 3% of cases associated with germline mutations in the mismatch repair pathway characteristic of Lynch syndrome (LS). The UK National Institute for Health and Care Excellence recommends screening for LS in all patients newly diagnosed with CRC, irrespective of age. The Yorkshire Cancer Research Bowel Cancer Improvement Programme includes a regional LS screening service for all new diagnoses of CRC. In the first 829 cases screened, 80 cases showed deficient mismatch repair (dMMR) including four cases showing areas with loss of expression of all four mismatch repair pro...
Patients undergoing surgery for bowel cancer now have a routine screening test to assess their genetic predisposition to this and other cancers (Lynch syndrome). A result indicating a high risk should trigger ...
Bowel Cancer UK found that 83% of hospital trusts do not provide 'life-saving' £200 test to identify Lynch syndrome - a genetic condition which increases a person's risk of Bowel Cancer
Cara Hoofe, from west London, is speaking out to raise awareness that bowel cancer can affect younger people. She has Lynch syndrome, an inherited condition raising risks of certain cancers.
Conclusion No SBN was found after 2 years. Surveillance of the small bowel by VCE does not seem to be warranted in asymptomatic LS patients. This study was registered in the Clinical Trials.gov registry with identifier NCT00898768. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract | open access Full text
LYNCH syndrome is a genetic condition which is the most common cause of hereditary bowel cancer.
Almost one third of UK hospitals do not routinely test patients with bowel cancer younger than age 50 years for Lynch syndrome, despite it increasing the risk for cancer recurrence, survey results suggest.Medscape Medical News
Pathologists says hospitals must offer younger patients screening for Lynch syndrome Related items fromOnMedica Gene found to be linked to increased risk of recurrence in bowel cancer More than half of new bowel cancer screen test invitees fail to take up offer Meeting cancer promises and more – a new model for NHS diagnostics? New test prompts rise in bowel screening uptake Early stage bowel cancer more likely to be picked up by screening
This article is protected by copyright. All rights reserved.
ConclusionsCMMRD is rare, but, especially in areas where founder mutations for LS and consanguinity are common, pediatricians should be aware of it since they are the first to encounter these children. Early diagnosis will enable tailored cancer surveillance in the entire family and a discussion regarding prenatal genetic diagnosis.