Protective effects of dammarane-type triterpenes from hydrolyzate of Gynostemma pentaphyllum against H2O2-induced injury and anti-hepatic fibrosis activities

In this study, phytochemical investigation of hydrolyzate of total G. pentaphyllum saponins led to the isolation of three previously undescribed triterpenes, Gypensapogenin R (1), Gypensapogenin S (2), and Gypensapogenin T (3). Their structures were mainly identified by 1D, 2D-NMR and HR-ESI–MS evidences. Anti-hepatic fibrosis activity was determined and the data showed that 2 and 3 exhibited more potent inhibitory effects (IC50 values 14.93 and 29.19, respectively) on the growth of t-HSC/Cl-6 cells than Silymarin (positive control), while having much weaker effect in the growth of normal cell. Additionally, all the compounds exhibited excellent increased the ratio of viability of H9c2 induced by H2O2. Here in we report isolation, structure elucidation, as well as the evaluation of the anti-hepatic fibrosis and cardiomyocytes oxidative injury activities of these three compounds. Graphical abstract
Source: Phytochemistry Letters - Category: Chemistry Source Type: research

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Authors: Kara SD, Amin U, Benbadis SR PMID: 31747527 [PubMed - as supplied by publisher]
Source: Expert Review of Neurotherapeutics - Category: Neurology Tags: Expert Rev Neurother Source Type: research
ConclusionWe provide an overview of mortality related to SE in China as the HQMS database covers a large number of cases of SE in China, making it one of the most efficient tools for mortality investigation. The use of electronic medical records in China creates several challenges and here we discuss lessons learned. The methodology will be improved and will be used in future studies.
Source: Seizure - Category: Neurology Source Type: research
Publication date: Available online 20 November 2019Source: The Lancet NeurologyAuthor(s): Jules Morgan
Source: The Lancet Neurology - Category: Neurology Source Type: research
Publication date: Available online 20 November 2019Source: The Lancet NeurologyAuthor(s): Zenobia Zaiwalla
Source: The Lancet Neurology - Category: Neurology Source Type: research
Publication date: Available online 21 November 2019Source: NeuropsychologiaAuthor(s): Mikko Hurme, Mika Koivisto, Linda Henriksson, Henry RailoAbstractSome neurological patients with primary visual cortex (V1) lesions can guide their behavior based on stimuli presented to their blind visual field. One example of this phenomenon is the ability to discriminate colors in the absence of awareness. These so-called patients with blindsight must have a neural pathway that bypasses V1, explaining their ability to unconsciously process stimuli. The pathways that have been most often hypothesized to be the cause of blindsight connec...
Source: Neuropsychologia - Category: Neurology Source Type: research
ConclusionData from this large, long-term study indicate that the nature, character, and frequency of SAEs in real-world settings are consistent with natalizumab's known safety profile. (Funded by Biogen; ClinicalTrials.gov identifiers: NCT00477113 and NCT00483847.)
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
This study examined the impact of psychiatric comorbidity on QOL in patients admitted to two level 4 epilepsy monitoring units (EMUs).MethodsIn this prospective observational study, 200 patients admitted to two level 4 EMUs completed standardized surveys including the Quality of Life in Epilepsy (QOLIE-31-P), Generalized Anxiety Disorder 7-item (GAD-7), Patient Health Questionnaire (PHQ-9), and Beck Depression Inventory-II (BDI-II). Hierarchal multiple regression was performed to assess impact on QOL.ResultsOf the 200 participants, 113 had a diagnosis of epilepsy, 36 had a diagnosis of PNES, and 51 were excluded for nondia...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
This study is in line with previous literature highlighting the difficulty in retrospectively differentiating SE from psychogenic status based on clinical events description recorded in the medical chart.
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Publication date: January 2020Source: Epilepsy &Behavior, Volume 102Author(s): Alexia Fasola, F.-Xavier Alario, Marion Tellier, Bernard Giusiano, Carlo Alberto Tassinari, Fabrice Bartolomei, Agnès TrébuchonAbstractPatients suffering from drug-resistant temporal lobe epilepsy show substantial language deficits (i.e., anomia) during their seizures and in the postictal period (postictal aphasia). Verbal impairments observed during the postictal period may be studied to help localizing the epileptogenic zone. These explorations have been essentially based on simple tasks focused on speech, thus disregarding t...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
ConclusionPatients and physicians' priorities in the management of epilepsy overlap only in part. Patients are satisfied with their caring physicians and less satisfied with communication and management of routine and emergency problems.
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
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