Interleukin ‐7 receptor α‐chain haplotypes differentially affect soluble IL‐7 receptor and IL‐7 serum concentrations in children with type 1 diabetes

ConclusionsChildren with T1D carrying autoimmunity risk‐ or protection‐associated IL7RA haplotypes had both lower sIL‐7R serum concentrations as compared to the reference haplotype, but only T1D children with the protective haplotype had lower IL‐7 serum levels. Our results suggest additional functional mechanisms of autoimmunity‐associated IL7RA variants independent from sIL‐7R mediated regulation of IL‐7 availability for T cells.

Source: Pediatric Diabetes - March 13, 2018 Category: Endocrinology Authors: Julia Seyfarth, Christian Lundtoft, Katharina F örtsch, Heinz Ahlert, Joachim Rosenbauer, Christina Baechle, Michael Roden, Reinhard W Holl, Ertan Mayatepek, Sebastian Kummer, Thomas Meissner, Marc Jacobsen Tags: ORIGINAL ARTICLE Source Type: research