Pulse release of doxazosin from hydroxyethylcellulose compression coated tablet: Mechanistic and in vivo study.

Pulse release of doxazosin from hydroxyethylcellulose compression coated tablet: Mechanistic and in vivo study. Int J Biol Macromol. 2014 Aug 29; Authors: Biswas N, Guha A, Sahoo RK, Kuotsu K Abstract Chronotherapeutically programmed hydroxyethylcellulose (HEC) based compression coated doxazosin tablets were prepared and the influence of disintegrants croscarmellose sodium, L-hydroxypropylcellulose (L-HPC), gellan gum on drug release and in vivo performance were investigated. Infrared spectroscopy and Differential scanning calorimetric studies did not indicate any excipient incompatibility in the tablets. The disintegrants induced a continuous water influx resulting in a rapid expansion of the membrane. The subsequent formation of fractures in to the coats leads to a fast drug release after an initial lag time. Release rates indicated that croscarmellose sodium and L-HPC were directly proportional to their concentration in the formulations. In vitro optimized croscarmellose sodium-HEC matrix showed significantly faster (p˂0.05) drug release (t90%=46min) after an initial lag of 243min. Disintegrant-HEC blended matrices were found significantly superior (p˂0.05) in terms of in vitro release and bioavailability in comparison to plain HEC matrices. Drug release kinetics followed modified power law and Weibull model (r ˃ 0.99). The mechanism involved in release was anomalous transport and super case II transport with matrix swelling. T...
Source: International Journal of Biological Macromolecules - Category: Biochemistry Authors: Tags: Int J Biol Macromol Source Type: research