Clinical and histologic characteristics of breast cancers in women with previous pathologic diagnosis of benign breast disease in Spain
Abstract
Women with a benign breast disease (BBD) have an increased risk of subsequent breast carcinoma. Information is scarce regarding the characteristics of breast carcinomas diagnosed after a BBD. Our aim was to point out the differences in clinical and histologic characteristics of breast carcinomas diagnosed in women with and without a previous pathologic diagnosis of BBD in the context of population‐based mammography screening. Retrospective cohort study of all women aged 50‐69 years who were screened at least once in a population‐based screening program in Spain, between 1994 and 2011 and followed up until December 2012. The mean follow‐up was 6.1 years. We analyzed 6645 breast carcinomas, of whom 238 had a previous pathologic diagnosis of BBD. Information on clinical and histologic characteristics was collected from pathology reports. Logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (95%CI) of occurrence of selected histologic characteristics of breast carcinomas in women with and without a previous BBD. Women with a previous BBD had a higher proportion of ductal carcinoma in situ (DCIS) compared with women without a BBD (22.1% and 13.6%, respectively). Among those diagnosed with an invasive breast carcinoma, women with previous BBD were more likely to be diagnosed with carcinomas sized >2 cm (OR = 1.46; 95%CI = 1.03‐2.08), metastatic positive (OR = 2.66; 95%CI = 1.21‐5.86), and with a high Ki‐67 p...
Source: The Breast Journal - Category: Cancer & Oncology Authors: Marta Rom án, Martin Caicoya, Josep Espinàs, Maria Sala, Isabel Torá‐Rocamora, Maria J. Quinta, Mar Vernet, Francina Saladié, Anabel Romero, Mar Sánchez, Marisa Baré, Carmen Vidal, S. Servitja, Carmen Natal, Joosep Corominas, Joana Ferrer, Ana Rod Tags: ORIGINAL ARTICLE Source Type: research
More News: Breast Carcinoma | Cancer | Cancer & Oncology | Carcinoma | DCIS (Ductal Carcinoma in Situ) | Ductal Carcinoma | Mammography | Pathology | Spain Health | Study | Women