What are the Short-Term Outcomes in Multiple Sclerosis Patients after Total Knee Arthroplasty?

J Knee Surg DOI: 10.1055/s-0038-1636836Due to the paucity of evidence, this study was conducted to evaluate: (1) unique characteristics of multiple sclerosis (MS) patients and (2) short-term clinical outcomes, of primary total knee arthroplasty (TKA) in patients with MS (MS-TKA) compared with matched non-MS patients. MS patients who underwent TKA were identified using the Nationwide Inpatient Sample (NIS) database. The study sample consisted of 10,884 patients with MS and 56,45,227 control cohort. Various patient factors were compared. To control for potential confounders, with the use of propensity scores, MS-TKA patients were matched (1:3) to non-MS-TKA patients and regression analyses were performed to compare perioperative complications, length of stay (LOS), and discharge dispositions. Patients with MS were younger, more likely to be females, on corticosteroids, and more likely to have muscle spasms and gait abnormalities. Annual frequency of TKAs in MS patients increased from 1.16/1,000 TKAs in 2002 to 2.48/1,000 TKAs in 2013 (p 
Source: Journal of Knee Surgery - Category: Orthopaedics Authors: Tags: Original Article Source Type: research

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ABSTRACT Objective: To investigate the potential relationship between the human leukocyte antigen (HLA) type (class I and II) and the response to several disease-modifying therapies (DMTs) in patients with multiple sclerosis (MS). Methods: We analyzed clinical data of 87 patients with MS at the beginning and end of each type of DMT including the disease duration, Expanded Disability Status Scale and Multiple Sclerosis Severity Score (MSSS). Genotyping of HLA-DRB1, HLA-DPB1, HLA-DQB1, HLA-A, HLA-B and HLA-C alleles were identified using high-resolution techniques. Statistical correlation between the HLA type and response to...
Source: Arquivos de Neuro-Psiquiatria - Category: Neurology Source Type: research
In this study, we correlated neurological outcomes from acute NMOSD relapses with delay to treatment, as well as demographic and clinical characteristics that influence prognosis.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Publication date: Available online 28 November 2018Source: Multiple Sclerosis and Related DisordersAuthor(s): Yara Dadalti Fragoso, Nise Alessandra C. Sousa, Soniza Vieira Alves-Leon, Ronaldo Maciel Dias, Maria Lucia V. Pimentel, Sidney Gomes, Marcus Vinicius M. Goncalves, Carla Vieira Stella, Carlos Bernardo Tauil, Andrea Anacleto, Caroline Vieira Spessotto, Eber Castro Correa, Audred C. Biondo Eboni, Alfredo Damasceno, Benito Damasceno, João Gabriel D. Farinhas, Rhea Sylvia de Souza Mota, Eduardo G. Almeida Nogueira, Valeria Coelho S.R. Pereira, Claudio ScorcineAbstractBackgroundThe 2015 criteria for diagnosing ne...
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
INTRODUCTIONUsually attributed to allergies or parasites (Seifert et. al Medline 2008) eosinophila is often overlooked. However hypereosinophilia (absolute eosinophil count>1.5 X 109/L on two separate exams one month apart or with pathologic confirmation) can have serious manifestations. When hypereosinophilia is associated with eosinophil-mediated organ damage or dysfunction, a hypereosinophilic syndrome (HES) exists.With an unpredictable course, eosinophilic infiltration commonly affects the skin (eczema), lung (dyspnea), &GIT (gastritis). However life-threatening damage to the CVS (myocarditis) or the CNS may occ...
Source: Blood - Category: Hematology Authors: Tags: 634. Myeloproliferative Syndromes: Clinical Source Type: research
ConclusionThese data suggest that an aggressive therapy should be established after NTZ with the shortest possible wash ‐out period. AHSCT after six months from NTZ withdrawal seems safe.This article is protected by copyright. All rights reserved.
Source: European Journal of Neurology - Category: Neurology Authors: Tags: Original Article Source Type: research
Publication date: Available online 3 November 2018Source: Journal of Clinical NeuroscienceAuthor(s): Yara Dadalti Fragoso, Joseph B. Bidin Brooks, Audred C. Biondo Eboni, Leticia Fezer, Paulo Diniz da Gama, Sidney Gomes, Marcus Vinicius M. Gonçalves, Suzana Nunes Machado, Rogerio Rizo Morales, Maria Lucia Vellutini Pimentel, Heloisa Helena Ruocco, Gutemberg Augusto Santos, Simone Scherpenhuijzen, Nise Alessandra Carvalho SousaAbstractPrevious infection with John Cunningham virus (JCV) increases the risk of progressive multifocal leukoencephalopathy in patients with multiple sclerosis (MS) undergoing treatment with n...
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
Authors: Paryzhak S, Dumych T, Mahorivska I, Boichuk M, Bila G, Peshkova S, Nehrych T, Bilyy R Abstract During NET formation, the content of neutrophils granules is released into the intercellular milieu. Consisting of many proteases and ROS species, formed NETs were shown to degrade cytokines (Schauer, Nat Med, 2014); while the content of neutrophil's azurophilic granules proved to contain glycosidases, secreted upon activation (Thaysen-Andersen, JBC, 2015), and formation of autoantibodies to neutrophil beta-glucoronidase was connected with the level of anti-MPO antibodies (Ab) (Martensson, Autoimmunity, 1992). Ta...
Source: Autoimmunity - Category: Allergy & Immunology Tags: Autoimmunity Source Type: research
ConclusionThis cohort is the first one compiled in Dakar. African multicentric epidemiological studies are needed.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
We report a 38-year old woman with adenocarcinoma of the cervix and LETM. Cervical and thoracic spine MRI showed hyperintense signal on T2W involving predominantly central spinal cord from the C4 level distally, including conus medullaris. In this patient corticosteroid therapy and therapeutic plasma exchange (TPE) courses were performed. On discharge, five weeks after TPE initiation, patient could walk with bilateral assistance. After a 16-month follow-up, her neurological finding was almost normal and MRI lesions disappeared. Thus, we present our patient as one of the rare cases of paraneoplastic LETM with excellent treatment response.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Publication date: Available online 5 September 2018Source: Multiple Sclerosis and Related DisordersAuthor(s): Anastasie M Dunn-Pirio, Christopher EcksteinAbstractSchilder's disease is a rare and aggressive central nervous system demyelinating disorder that is typically monophasic and steroid responsive. Here, we present an unusual case of a teenager with Schilder's disease who was treated with corticosteroids and had a clinical and radiographic recurrence nearly one year after the initial presentation.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
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