Fusobacterium nucleatum Potentiates Intestinal Tumorigenesis in Mice via a Toll-Like Receptor 4/p21-Activated Kinase 1 Cascade

ConclusionsFusobacterium nucleatum potentiates intestinal tumorigenesis inApcMin/+ mice via a TLR4/p-PAK1/p- β-catenin S675 cascade.Fusobacterium nucleatum-induced intestinal tumorigenesis can be inhibited by TAK-242, implicating TLR4 as a potential target for the prevention and therapy ofF. nucleatum-related colorectal cancer.
Source: Digestive Diseases and Sciences - Category: Gastroenterology Source Type: research