PET imaging could help personalize cancer treatment

Researchers have developed a same-day, noninvasive PET imaging approach to...Read more on AuntMinnie.comRelated Reading: FDG-PET/CT predicts outcomes in pediatric osteosarcoma Artificial intelligence guides lower PET tracer dose PET tracer could better assess lung ailments SNMMI posts criteria for somatostatin receptor PET Deep learning analyzes PET for signs of dementia
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news

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Publication date: Available online 16 August 2018Source: Chemico-Biological InteractionsAuthor(s): Gustavo Roberto Thomé, Vitor Antunes Oliveira, Maria Rosa Chitolina Schetinger, Rogério Aquino Saraiva, Diego Souza, Oscar Endrigo Dorneles Rodrigues, João Batista Teixeira Rocha, Rafael Porto Ineu, Maria Ester PereiraAbstractThe present study evaluated the neuroprotective effects of one selenium-containing AZT derivative compound (S1073) in memory and learning impairment caused by Intracerebroventricular-streptozotocin (ICV-STZ). ICV-STZ in mice causes impairment of energy metabolism with oxidative damag...
Source: Chemico Biological Interactions - Category: Biochemistry Source Type: research
In this study, a simple but sensitive electrochemiluminescence (ECL) biosensor has been designed for HAase detection based on the electrostatic interaction of anionic hyaluronic acid (HA) and cationic luminous reagent Ru(bpy)32+. Ru(bpy)32+ is adsorbed on HA through electrostatic interaction to form HA-Ru(bpy)32+ complex. The Ru(bpy)32+ in the HA-Ru(bpy)32+ complex cannot be filtered out because of its large molecular weight. In the presence of HAase, the HA in HA-Ru(bpy)32+ can be cleaved into fragments by enzymatic hydrolysis. As a result, the Ru(bpy)32+ attached on the HA fragments can be separated from the HA-Ru(bpy)32...
Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research
Publication date: 1 November 2018Source: Inorganica Chimica Acta, Volume 483Author(s): Yeşim Salman, Fırat Barış Barlas, Murat Yavuz, Kerem Kaya, Suna Timur, Fatma Çetin TelliAbstractFour novel dinuclear Cu(II) complexes (1a–4a) have been prepared from ONO-tridentate chiral Schiff base derivatives of chloralose (1–4). All the new complexes (1a–4a) have been characterized by Fourier transform infrared spectroscopy, UV–visible spectroscopy and elemental analysis. The complex 2a was further characterized by X-Ray crystallography. And also, the magnetic susceptibility measurement of this comp...
Source: Inorganica Chimica Acta - Category: Chemistry Source Type: research
Reese Witherspoon and Keith Urban are among the stars joining the sixth Stand Up To Cancer telethon on Sept. 7.
Source: ABC News: Health - Category: Consumer Health News Tags: Health Source Type: news
BOWEL cancer risk could be reduced by making some diet or exercise changes. Eating more of this cheap vegetable could prevent the deadly disease, scientists have claimed. Its preventative effects are “striking”, they said.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Muhammad Junaid, from a small village in Mirpur Khas, Pakistan, suffers from Retinoblastoma - a type of carcinoma that usually affects children under the age of five.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
To outwit cancer, researchers are working on better ways to teach patients' immune system to root out and kill malignant cells. A promising approach involves cells that attack cancer two ways at once.(Image credit: Pearl Mak/NPR)
Source: NPR Health and Science - Category: Consumer Health News Authors: Source Type: news
Low-grade osteosarcoma (LGOS) encompasses low-grade central osteosarcoma (LGCOS) and parosteal osteosarcoma (POS). LGOSs are characterized by a supernumerary ring and giant rod chromosomes containing the 12q13-15 amplicon. The fibroblast growth factor receptor substrate 2 (FRS2) gene is located close to MDM2 and CDK4. Recent studies identified consistent amplification of FRS2 gene in atypical lipomatous tumor/well-differentiated liposarcoma and dedifferentiated liposarcoma. The aim of this study was to evaluate the frequency of FRS2 amplification and its relationship with the clinicopathologic features of LGOSs. The amplif...
Source: The American Journal of Surgical Pathology - Category: Pathology Tags: Original Articles Source Type: research
This study examines whether cancers that are classified as HER2-amplified with an alternate probe are clinicopathologically similar to those that are classified as such using the HER2/CEP17 probe. Reports for 1201 breast cancers were reviewed, and clinicopathologic findings were compared between HER2/CEP17-equivocal cases that became HER2-amplified using the alternate probe (group A: n=48), HER2-amplified cases using the HER2/CEP17 probe (group B: n=169), and HER2-nonamplified cases using the HER2/CEP17 probe (group C: n=910). Of 1201 cases tested using the HER2/CEP17 probe, 169 (14%) were HER2-amplified, 122 (10%) were eq...
Source: The American Journal of Surgical Pathology - Category: Pathology Tags: Original Articles Source Type: research
The immune regulatory enzyme indoleamine-2,3-dioxygenase (IDO-1) suppresses T cell responses and may reduce efficacy of therapies targeting immune checkpoints such as programmed death receptor-1/programmed death ligand-1 (PD-1/PD-L1). Early phase clinical trials combining IDO-1 and PD-1/PD-L1 inhibitors have shown some promise in non–small cell lung cancers (NSCLCs). However, the coexpression of IDO-1 and PD-L1 has not been thoroughly investigated, and the potential for IDO-1 immunohistochemical expression as a therapeutic biomarker is unknown. One hundred two cases of NSCLC (51 adenocarcinomas, 9 adenosquamous carci...
Source: The American Journal of Surgical Pathology - Category: Pathology Tags: Original Articles Source Type: research
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