Metformin use during pregnancy linked to heavier babies

A study in theJournal of Clinical Endocrinology& Metabolism reports that PCOS patients who take metformin during pregnancy are more likely to have heavier babies.Medpage Today
Source: Society for Endocrinology - Category: Endocrinology Source Type: news

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This study's objective was to evaluate the effect of a microvibration culture system (MVC) during IVM and/or in vitro culture (IVC) on the clinical outcomes and the embryonic development potential of human GV-stage oocytes collected from human chorionic gonadotropin (HCG)-primed IVM and fertilization-embryo transfer (IVM/F-ET) cycles of patients with polycystic ovaries (PCO). A total of 206 HCG-primed IVM/F-ET cycles were divided into four groups according to the microvibration and static culture system applied during IVM and/or IVC: Group SS (static system during both IVM and IVC); Group SV (static system during IVM alter...
Source: Reproductive Biology - Category: Reproduction Medicine Authors: Tags: Syst Biol Reprod Med Source Type: research
Katherine Samaras1,2,3*, Henrik Tevaerai4, Michel Goldman5, Johannes le Coutre6,7 and Jeff M. P. Holly8 1Department of Endocrinology, St Vincent's Hospital, Darlinghurst, NSW, Australia 2Diabetes and Metabolism, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia 3St Vincent's Hospital, St Vincent's Clinical School, Darlinghurst, NSW, Australia 4Bern University Hospital, Bern, Switzerland 5Institute for Interdisciplinary Innovation in Healthcare, Universite Libre de Bruxelles, Bruxelles, Belgium 6Department of Medicine, Imperial College London, London, United Kingdom 7Nes...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
ConclusionsThere is insufficient evidence of an effect of inositols on ovarian reserve markers and to support their use as pre ‐treatment before IVF/ICSI in women with polycystic ovary syndrome.This article is protected by copyright. All rights reserved.
Source: Acta Obstetricia et Gynecologica Scandinavica - Category: OBGYN Authors: Tags: Systematic review Source Type: research
Michael Grynberg1,2,3,4* and Julie Labrosse2 1AP-HP, Department of Reproductive Medicine &Fertility Preservation, Hôpital Antoine Béclère, Clamart, France 2AP-HP, Department of Reproductive Medicine &Fertility Preservation, Hôpital Jean Verdier, Bondy, France 3INSERM U1185, University Paris-Sud, Le Kremlin-Bicêtre, France 4INSERM U1133, University Paris Diderot, Paris, France The management of low prognosis patients in ART represents a challenge for reproductive specialists. Different profiles and biologic characteristics have been identified among these patients. Indeed...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
MONDAY, April 15, 2019 -- In pregnant women with polycystic ovary syndrome (PCOS), metformin treatment from the late first trimester until delivery might reduce the risk for late miscarriage and preterm birth but does not prevent gestational...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
Metformin ups likelihood of full-term births, reduces late miscarriages in women with PCOS, but doesn't impact gestational diabetes. Study also hints giving drug pre-pregnancy could be beneficial.Medscape Medical News
Source: Medscape Diabetes Headlines - Category: Endocrinology Tags: Diabetes & Endocrinology News Source Type: news
Jie Cai1†, Yi Zhang1†, Yuying Wang1, Shengxian Li1, Lihua Wang1, Jun Zheng1, Yihong Jiang1, Ying Dong1, Huan Zhou1, Yaomin Hu1, Jing Ma1, Wei Liu1,2*† and Tao Tao1*† 1Division of Endocrinology and Metabolism, Department of Internal Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Pudong, China 2Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Center for Reproductive Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Pudong, China Background: Infertility and dyslipidemia are frequently present in both women...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Marcia H. Ratner, Vidhya Kumaresan and David H. Farb* Laboratory of Molecular Neurobiology, Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA, United States Memory dysfunction is a symptomatic feature of many neurologic and neuropsychiatric disorders; however, the basic underlying mechanisms of memory and altered states of circuitry function associated with disorders of memory remain a vast unexplored territory. The initial discovery of endogenous neurosteroids triggered a quest to elucidate their role as neuromodulators in normal and diseased brain functio...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Miguel del Campo1, Beatriz Piquer1, Jason Witherington2, Arun Sridhar2 and Hernan E. Lara1* 1Laboratory of Neurobiochemistry, Faculty of Chemistry and Pharmaceutical Sciences, Centre for Neurochemical Studies in Neuroendocrine Diseases, Universidad de Chile, Santiago, Chile 2Galvani Bioelectronics, Stevenage, United Kingdom Sympathetic innervation of the ovary in rodents occurs via two routes: the superior ovarian nerve (SON), which runs along the ovarian ligament, and the plexus nerve (PN), which is mainly associated with the vasculature. SON and ovarian norepinephrine (NE) levels play a major role in regulatin...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Publication date: Available online 18 January 2019Source: Reproductive BioMedicine OnlineAuthor(s): Hui Chang, Liangzhen Xie, Hang Ge, Qi Wu, Yan Wen, Duojia Zhang, Yuehui Zhang, Hongli Ma, Jingshu Gao, Chi Chiu Wang, Elisabet Stener-Victorin, Ernest HY Ng, Xiaoke WuAbstractResearch questionWhat is the association between hyperhomocysteinaemia (HHCY), metabolic syndrome, and reproductive outcomes among women with polycystic ovary syndrome (PCOS).DesignA secondary analysis of PCOSAct with 21 sites in China. A total of 1000 women with PCOS were enrolled; 936 women with baseline homocysteine (HCY) were analysed.ResultsHigher ...
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research
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