Visual probing of rectal neoplasia-near-infrared interrogation of primary tumours and secondary lymph nodes.

Visual probing of rectal neoplasia-near-infrared interrogation of primary tumours and secondary lymph nodes. Minerva Chir. 2018 Feb 21;: Authors: Khokhar HA, Loughman E, Khogali M, Mulligan N, O'Shea DF, Cahill RA Abstract Laparoscopic and endoscopic colorectal intervention and operations have their basis in real-time, image-based decision-making and step-by-step sequenced technical progress. The capacity to visualise accurately malignant disease wherever it may be including within the primary lesion and its draining lymph node basin as well as at potential sites of metastatic harbour (i.e. peritoneum, liver and lung) would allow more accurate surgery at the time of operation and enable personalised, stratified surgical intervention. In addition, such capacity could efficiently compress the diagnostic and therapeutic stages of a patient's progress from presentation, through work-up and onto appropriate treatment, important in this era of restricted resource and increased user demand. Near-infrared endolaparoscopic illumination enables broad spectral imaging of tissue in situ, most often, at present, in conjunction with the approved safe and low-cost fluorophore indocyanine green. While additional targeted agents are in development, here we detail how this developed and available technology may be used as a visual probe of neoplasia to inform surgeons regarding functional, tissue characterisation through the direct observation of meta...
Source: Minerva Chirurgica - Category: Surgery Tags: Minerva Chir Source Type: research