U0126 protects hippocampal CA1 neurons against forebrain ischemia-induced apoptosis via the ERK1/2 signaling pathway and NMDA receptors.

CONCLUSION: These findings suggest a novel mechanism by which the ERK1/2 signaling pathway affects the post-I/R apoptosis of CA1 pyramidal neurons, which will provide a therapeutic target for the treatment of stroke. PMID: 29473447 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/29473447?dopt=Abstract

Source: Neurological Research - February 25, 2018 Category: Neurology Tags: Neurol Res Source Type: research

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