Reactivation of BK Polyomavirus during Pregnancy, Vertical Transmission, and Clinical Significance: A Meta-Analysis

BK Polyomavirus is a small double-stranded circular DNA virus in the Polyomaviridae family, infecting a substantial proportion of humans worldwide [1 –3]. Primary infection with BK virus occurs during early childhood and is usually asymptomatic [1]. BK seroprevalence increases with age (approximately 70% of children are infected by the age of 10 years, and greater than 80% of adults become BK seropositive) [1,4]. In immunosuppressed states, esp ecially after kidney transplantation, reactivation of BK virus can cause BK viremia and BK nephropathy, associated with allograft loss [3].

Source: Journal of Clinical Virology - February 24, 2018 Category: Virology Authors: Wisit Cheungpasitporn, Charat Thongprayoon, Iasmina M. Craici, Konika Sharma, Supavit Chesdachai, Nadeen J. Khoury, Amy S. Ettore Source Type: research