GSE100882 SAMHD1 is recurrently mutated in T-cell prolymphocytic leukemia [RNA-seq]

Contributors : Ludger Klein-Hitpass ; Patricia JohanssonSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe identified novel recurrent genetic lesions in T-PLL affecting genes involved in JAK/STAT signaling (PTPRC), epigenetic regulation (PRDM2), or DNA damage repair (SAMHD1, PARP10, HERC1, HERC2). Mutations of the tumor suppressor gene SAMHD1 causing amino-acid exchanges or protein truncations as well as copy number variations in SAMHD1 were seen in 20% of cases.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research