Neuropathologic features of the hippocampus and amygdala in cats with familial spontaneous epilepsy.

CONCLUSIONS AND CLINICAL RELEVANCE Findings suggested that the lower numbers of neurons in the CA3 subregion of the hippocampus and the central nucleus of the amygdala were endophenotypes of familial spontaneous epilepsy in cats. In contrast to results of other veterinary medicine reports, severe epilepsy-related neuropathologic changes (eg, hippocampal sclerosis, amygdaloid sclerosis, mossy fiber sprouting, and granule cell pathological changes) were not detected in FSECs. Despite the use of a small number of cats with infrequent seizures, these findings contributed new insights on the pathophysiologic mechanisms of genetic-related epilepsy in cats.
PMID: 29466043 [PubMed - in process]

Source: American Journal of Veterinary Research - February 22, 2018 Category: Veterinary Research Authors: Yu Y, Hasegawa D, Hamamoto Y, Mizoguchi S, Kuwabara T, Fujiwara-Igarashi A, Tsuboi M, Chambers JK, Fujita M, Uchida K Tags: Am J Vet Res Source Type: research