Age-Dependent Oxidation of Extracellular Cysteine/Cystine Redox State (Eh(Cys/CySS)) in Mouse Lung Fibroblasts is Mediated by a Decline in Slc7a11 Expression.

In conclusion, our study reveals Slc7a11 is the key regulator of age-dependent changes in extracellular Eh(Cys/CySS) in primary mouse lung fibroblasts, and its effects are not dependent on GSH synthesis. PMID: 29458149 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/29458149?dopt=Abstract

Source: Free Radical Biology and Medicine - February 16, 2018 Category: Biology Authors: Zheng Y, Ritzenthaler JD, Burke TJ, Otero J, Roman J, Watson WH Tags: Free Radic Biol Med Source Type: research

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