Transcriptional Profiling of Synovium in a Porcine Model of Early Post ‐traumatic Osteoarthritis

In conclusion, this study confirmed an increased synovial expression of genes that may serve as targets to prevent cartilage degradation, including MMP1, MMP13, and ADAMTS4, in knees with microscopic synovitis and cartilage proteoglycan loss. Attractive novel targets include regulators of embryonic developmental processes in synovium. This article is protected by copyright. All rights reserved

Source: Journal of Orthopaedic Research - December 1, 2017 Category: Orthopaedics Authors: Jakob T. Sieker, Benedikt L. Proffen, Kimberly A. Waller, Kaitlyn E. Chin, Naga Padmini Karamchedu, Matthew R. Akelman, Gabriel S. Perrone, Ata M. Kiapour, Johannes Konrad, Braden C. Fleming, Martha M. Murray Tags: Research Article Source Type: research