Levetiracetam Bests Phenobarbital in Infantile Epilepsy (CME/CE)
(MedPage Today) -- Study addresses mismatch between clinical practice and regulatory approval
The objective of this study was to develop an in-situ gel containing lorazepam (LZM) loaded nanostructured lipid carriers (NLCs) for direct nose-to-brain delivery in order to increase drug therapeutic efficacy in the treatment of epilepsy. Accordingly, LZM loaded NLCs were formulated using emulsification solvent diffusion and evaporation method; then the effects of the formulation variables on different physicochemical characteristics of NLCs were investigated. Thermosensitive in-situ gels containing LZM-NLCs were prepared using a combination of chitosan and β-glycerol phosphate (β-GP). The anticonvulsant efficac...
Charlotte Figi, a child with a catastrophic type of epilepsy who went on to inspire a CBD movement, has passed away at age 13. CNN's Dr. Sanjay Gupta reflects on her life.
Publication date: June 2020Source: Epilepsy &Behavior, Volume 107Author(s): María Puig-Molto, Emilio Pol-Yanguas, Lidia Segarra, Blanca Lumbreras
Authors: Li R, He M, Wu B, Zhang P, Zhang Q, Chen Y Abstract α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors are the predominant mediators of glutamate-induced excitatory neurotransmission. It is widely accepted that AMPA receptors are critical for the generation and spread of epileptic seizure activity. Dysfunction of AMPA receptors as a causal factor in patients with intractable epilepsy results in neurotransmission failure. Brain-specific serine/threonine-protein kinase 1 (SAD-B), a serine-threonine kinase specifically expressed in the brain, has been shown to regulate AMPA receptor-m...
Publication date: Available online 8 April 2020Source: Psychiatric Clinics of North AmericaAuthor(s): Benjamin Tolchin, Lawrence J. Hirsch, William Curt LaFrance
Publication date: June 2020Source: Epilepsy &Behavior, Volume 107Author(s): Andreu Massot-Tarrús, Kevin P. White, Seyed Reza Mousavi, Susan Hayman-Abello, Brent Hayman-Abello, Seyed M. Mirsattari
In conclusion; Beta-Propeller Protein Associated Neurodegeneration should be considered as an option in the diagnosis of female patients with clinical findings of epilepsy, growth retardation and autism, with unspecified etiology. PMID: 32253879 [PubMed - in process]
In this report, we present a 5-year-old boy who had dysmorphic features, hypotonia, developmental and mental delay, epileptic spasms, recurrent apnea and respiratory failure that led to the diagnosis of an unreported mutation of a rare form of CDG-Ix. This mutation in the STT3B gene affects the catalytic subunit of the oligosaccharyltransferase and the recipient substrate properties, which in part have the same functions in N-glycosylation. A novel homozygous mutation in the STT3B presence of c.38C> G that encodes p.S13W (p.Ser13Trp) was detected with next generation sequencing. The CDG clinical spectrum can be unusual,...
In conclusion; Beta-Propeller Protein Associated Neurodegeneration should be considered as an option in the diagnosis of female patients with clinical findings of epilepsy, growth retardation and autism, with unspecified etiology. PMID: 32253874 [PubMed - in process]
A Colorado girl with a rare form of epilepsy whose recovery inspired the name of a medical marijuana oil that drew families to the state has died