A regulatory circuitry between miR-193a/miR-600 and WT1 enhances leukemogenesis in acute myeloid leukemia

MicroRNAs, which inhibit target gene expression through mainly binding 3'-untranslated regions (3'UTR) or seldom binding coding sequence (CDS) of target gene mRNA, are class of small non-coding RNAs[1]. MiRNAs modulate several important biological processes, such as apoptosis, cell cycle, proliferation, differentiation, and epigenetic changes[2, 3]. Single miRNA probably regulates hundreds of target genes and one single gene might be regulated by several miRNAs. Thus, miRNA-mRNA regulatory net plays an important role in diverse biological processes.

Source: Experimental Hematology - February 13, 2018 Category: Hematology Authors: Haiying Li, Chongyun Xing, Bin Zhou, Haige Ye, Jianhua Feng, Jianbo Wu, Shenmeng Gao Source Type: research